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Achalasia is characterized by difficulty in swallowing, regurgitation, and sometimes chest pain.

Diagnosis is reached with esophageal manometry and barium swallow radiographic studies.

Various treatments are available, although none cures the condition. Certain medications or Botox may be used in some cases, but more permanent relief is brought by esophageal dilatation and surgical cleaving of the muscle (Heller myotomy).

The most common form is primary achalasia, which has no known underlying cause. It is due to the failure of distal esophageal inhibitory neurons. However, a small proportion occurs secondary to other conditions, such as esophageal cancer, Chagas disease or Triple-A syndrome.

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