Lucio phenomenon is a severe complication of multibacillary leprosy that is marked by blue hemorrhagic plaques and necrotic ulcerations. The bacilli may extend to the endothelial cells along with the appearance of necrotic epidermis and vasculitis with thrombus formation and endothelial proliferation.

It is an uncommon reaction that occurs in patients with diffuse lepromatous leprosy and is characterized by severe, necrotizing, cutaneous lesions.

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