Porphyria cutanea tarda (PCT) is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase (UROD) is deficient. Risk factors for porphyria cutanea tarda are alcohol use, hepatitis C or HIV infections, smoking, and certain medications. 24-hour urine collection demonstrates an elevated level of uroporphyrins.

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