Zinc deficiency can lead to loss of appetite, growth retardation and impaired immune function. In severe cases, it can result in hair loss, diarrhea and delayed sexual maturation. Zinc deficiency can be treated through diet. A skin biopsy shows irregular orthokeratosis and parakeratosis, a reduced granular layer, and pallor of the keratinocytes in the upper epidermal layers suggestive of zinc deficiency. Laboratory studies confirms a low zinc level. The patient improves with oral zinc sulfate supplementation.

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